Understanding the Interaction Between Ibuprofen and Weed

Cannabis, commonly referred to as weed, has long been an integral part of society. People have been consuming it in a variety of forms, including smokable flowers, oils, edibles and more, for centuries. With medical marijuana becoming more widely accepted and accepted as a legitimate form of treatment, it has become increasingly important to understand the impact and interaction of commonly-used drugs and weed (cannabis). This article will focus on the interaction between ibuprofen and weed.

What is Ibuprofen?

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) most commonly used to treat pain, inflammation, and fever. It is an over-the-counter (OTC) drug, meaning it is available without a doctor’s prescription. Ibuprofen is also used to treat headaches, muscle aches, arthritis, menstrual cramps, and various other conditions.

What is Weed?

Weed, more formally known as cannabis, is a plant used for recreational and medicinal purposes. It is made up of many compounds, including THC (tetrahydrocannabinol) and CBD (cannabidiol). THC is the compound that produces the psychoactive effects associated with weed, while CBD is the compound most famously known for medical purposes, such as pain and anxiety relief.

How Does Ibuprofen Interact with Weed?

It is important to note that interactions between ibuprofen and weed can differ between different individuals, but there are some trends that can be noted. When taking ibuprofen, it is best to avoid consuming excessive amounts of THC at the same time as taking ibuprofen because it has the potential to worsen the symptoms of the drug. Additionally, when consuming THC, it is important to understand the delayed onset sometimes associated with edibles; consuming more than necessary could result in negative side effects and adverse interactions with ibuprofen.

Benefits of Taking Ibuprofen Before Cannabis

Although there is little scientific research examining the effects of ibuprofen and cannabis when taken together, there are some potential benefits to taking ibuprofen before cannabis. One potential benefit is that ibuprofen has the ability to reduce inflammation throughout the body, which may reduce the headache or migraine-like feeling that comes with consuming cannabis. Additionally, some studies have suggested that ibuprofen may improve the overall experience of consuming cannabis, as it may reduce the anxious and anxious-like side effects of consuming an excessive amount of THC.

Side Effects of Taking Ibuprofen Before Cannabis

As with any medication, ibuprofen has the potential for negative side effects and interactions. Some of the most common side effects of ibuprofen when taken before cannabis include stomach upset, nausea, vomiting, dizziness, and drowsiness. It is important to note that many of these side effects can be minimized by taking the drug with food or water and avoiding large doses of ibuprofen. Additionally, utilizing cannabis in lower doses may help to minimize these side effects.

The Dos and Don’ts of Taking Ibuprofen Before Consuming Cannabis

When taking ibuprofen and cannabis, it is important to take the time to understand potential interactions and the potential benefits and side effects. To get the most out of the experience, here are a few dos and don’ts of taking ibuprofen before consuming cannabis:


  • Take ibuprofen with food or water to best avoid stomach upset
  • Start with a low dose of both ibuprofen and cannabis to gauge tolerance
  • Utilize smaller doses of cannabis to limit anxious side effects
  • Consult a healthcare provider for any concerns


  • Don’t take ibuprofen on an empty stomach
  • Don’t mix ibuprofen and cannabis with alcohol
  • Don’t take excessively high doses of ibuprofen and cannabis
  • Don’t take ibuprofen or cannabis if you are pregnant

Although research is limited on the potential interactions between ibuprofen and cannabis, it is important to understand the potential benefits as well as the potential side effects. When taken carefully, ibuprofen and cannabis can offer a variety of benefits, such as reducing inflammation and minimizing anxious side effects. As always, it is important to make sure to discuss any concerns or worries with a healthcare provider before taking ibuprofen and cannabis together.